CTZ is used to relieve symptoms of:
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Cetirizine is a selective H1-antihistamine:
Peak level in adults: ~257 mcg/L within 1 hour (faster in children)
Half-life: ~11 hours
Absorption: Consistent, not significantly affected by food
Excretion: Mostly via urine (renal clearance ~30 ml/min)
Pregnancy (Category B): Use only if clearly needed
Lactation: Passes into breast milk – use with caution
Elderly: Reduced clearance – dose adjustment may be needed
Hepatic/Renal Impairment: Reduced clearance; half-life may double or triple
Most common: Drowsiness (somnolence)
Usually mild and well-tolerated
No major interactions observed with:
Known allergy to Cetirizine or Hydroxyzine
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